Concluded projects (and related production)
1. Potential application of nasal pramlintide aiming metabolic outcomes.
Student involved: Milena dos Santos Almeida.
Related production: Submitted.
2. Impact of sleep perturbation on glucose and lipid metabolism.
Student involved: Natália S Tonet.
Related production: Tonet NS, da Silva Marçal DF, da Silva FN, Brunetta HS, Mori MADS, Dos Santos GJ, Moreira ELG, Rafacho A. Moderate chronic sleep perturbation impairs glucose and lipid homeostasis in rats. Sleep. 2024 Jul 11;47(7):zsae118. doi: 10.1093/sleep/zsae118. PMID: 38788154.
3. Endocrine pancreas distribution in frugivorous, insectivorous and nectarivorous bats: a descriptive study.
Student involved: Morgana Contini
Related production: Contini M, Beguelini MR, Ruiz T, Taboga SR, Rafacho A. Comparative study of endocrine pancreatic tissue in bats: Assessing variations among frugivorous, insectivorous, and nectarivorous diets. Tissue Cell. 2024 Jun;88:102413. doi: 10.1016/j.tice.2024.102413. Epub 2024 May 17. PMID: 38772274.
4. Acute effects of malathion pesticide on cellular and ultrastructural parameters of pancreatic beta cells.
Student involved: José Rodrigo N Martins
Related production: da Silva FN, Zimath PL, do Amaral TA, Martins JRN, Rafacho A. Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats. Life Sci. 2023 Jun 1;322:121660. doi: 10.1016/j.lfs.2023.121660. Epub 2023 Apr 1. PMID: 37011876.
5. Effects of a combination of olanzapine and dexamethasone on glucose metabolism.
Student involved: Flávia N da Silva
Related production: da Silva FN, Zimath PL, do Amaral TA, Martins JRN, Rafacho A. Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats. Life Sci. 2023 Jun 1;322:121660. doi: 10.1016/j.lfs.2023.121660. Epub 2023 Apr 1. PMID: 37011876.
6. Effects of mometasone furoate on metabolism: looking for a new GC with less adverse effects.
Students involved: Priscila Lais Zimath and Milena dos Santos Almeida
Related production: Zimath PL, Almeida MS, Bruxel MA, Rafacho A. Oral mometasone furoate administration preserves anti-inflammatory action with fewer metabolic adverse effects in rats. Biochem Pharmacol. 2023 Apr;210:115486. doi: 10.1016/j.bcp.2023.115486. Epub 2023 Mar 7. PMID: 36893817.
Zimath PL, Almeida MS, Bruxel MA, Rafacho A. Oral mometasone furoate administration preserves anti-inflammatory action with fewer metabolic adverse effects in rats. Biochem Pharmacol. 2023 Apr;210:115486. doi: 10.1016/j.bcp.2023.115486. Epub 2023 Mar 7. PMID: 36893817.
7. Distribution and mass of pancreatic endocrine cells in bats: a functional and structural approach based in different diet habits.
Student involved: Guilherme Durante Cruz
Related production: Contini M, Cruz GD, Althoff SF, Freitas MB, Taboga SR, Rafacho A. Heterogeneity in the preferential diet of neotropical bats impacts the pancreatic islet mass and α and β cell distribution. Gen Comp Endocrinol. 2024 Mar 1;348:114449. doi: 10.1016/j.ygcen.2024.114449. Epub 2024 Jan 10. PMID: 38216095.
8. Impact of organophosphorate pesticide on glucose homeostasis during gestational period and offspring.
Students involved: Maciel Alencar Bruxel, Flavia N da Silva
Related production: Bruxel MA, da Silva FN, da Silva RA, Zimath PL, Rojas A, Moreira ELG, Quesada I, Rafacho A. Preconception exposure to malathion and glucose homeostasis in rats: Effects on dams during pregnancy and post-term periods, and on their progeny. Environ Pollut. 2023 Jan 1;316(Pt 2):120633. doi: 10.1016/j.envpol.2022.120633. Epub 2022 Nov 9. PMID: 36370973.
9. Antiobesity potential of peptide 19 in a HFD mice model.
Post doc involved: Renata Silvério Deluca
Related production: Silvério R, Barth R, Heimann AS, Reckziegel P, Dos Santos GJ, Romero-Zerbo SY, Bermúdez-Silva FJ, Rafacho A, Ferro ES. Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice. Int J Mol Sci. 2022 Apr 7;23(8):4082. doi: 10.3390/ijms23084082. PMID: 35456900; PMCID: PMC9030859.
10. Evaluation of IDE involvement in physiological insulin fluctuactions during gestation.
Post doc involved: Ana Paula Dambros Taschetto, Renata Silvério Deluca
Related production: Taschetto APD, Zimath PL, Silvério R, Dos Santos C, Boschero AC, Dos Santos GJ, Rafacho A. Reduced insulin sensitivity and increased β/α cell mass is associated with reduced hepatic insulin-degrading enzyme activity in pregnant rats. Life Sci. 2021 Jul 15;277:119509. doi: 10.1016/j.lfs.2021.119509. Epub 2021 Apr 15. PMID: 33865877.
11. Glucose and lipid homeostasis in rats with parkinson’s-like phenotype induced 6-OHDA.
Student involved: Felipe Azevedo Gomes
Related production: Gomes FA, Flores RA, Bruxel MA, da Silva FN, Moreira ELG, Zoccal DB, Prediger RD, Rafacho A. Glucose Homeostasis Is Not Affected in a Murine Model of Parkinson’s Disease Induced by 6-OHDA. Front Neurosci. 2019 Jan 9;12:1020. doi: 10.3389/fnins.2018.01020. PMID: 30686986; PMCID: PMC6333712.
12. Effects of metformin and sitagliptin on the metabolic dysfunctions caused by glucocorticoid excess.
Student involved: Francielle Battista Duarte Ferreita
Related production: Figueiredo BS, Ferreira FBD, Barbosa AM, Dos Santos C, Ortsäter H, Rafacho A. Coadministration of sitagliptin or metformin has no major impact on the adverse metabolic outcomes induced by dexamethasone treatment in rats. Life Sci. 2021 Dec 1;286:120026. doi: 10.1016/j.lfs.2021.120026. Epub 2021 Oct 8. PMID: 34627773.
13. Investigation of hepatic and adipose tissue molecular mechanisms involved in the hypertriacylglyceridemia observed during normal- and glucocorticoid-influenced gestation in rats.
Student involved: Katia Motta
Related production: Motta K, Gomes PRL, Sulis PM, Bordin S, Rafacho A. Dexamethasone Administration During Late Gestation Has No Major Impact on Lipid Metabolism, but Reduces Newborn Survival Rate in Wistar Rats. Front Physiol. 2018 Jul 3;9:783. doi: 10.3389/fphys.2018.00783. PMID: 30018561; PMCID: PMC6038799.
14. Glucose metabolism in adult rats born from rats treated with dexamethasone before copulation.
Student involved: Flávia Natividade da Silva
Related production: Santos CD, da Silva JS, Brunetta HS, Chagas TR, Zoccal DB, Nunes EA, Rafacho A. Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration. J Nutr Biochem. 2021 Apr;90:108572. doi: 10.1016/j.jnutbio.2020.108572. Epub 2020 Dec 31. PMID: 33388348.
15. Combination of fructose and prednisolone administration: sought for new experimental models with glucose homeostasis imbalance and the impact of fish oil supplementation.
Students involved: Cristiane dos Santos & Julia S da Silva
Related production: Santos CD, da Silva JS, Brunetta HS, Chagas TR, Zoccal DB, Nunes EA, Rafacho A. Impact of combined long-term fructose and prednisolone intake on glucose and lipid homeostasis in rats: benefits of intake interruption or fish oil administration. J Nutr Biochem. 2021 Apr;90:108572. doi: 10.1016/j.jnutbio.2020.108572. Epub 2020 Dec 31. PMID: 33388348.
16. Repercurssions of the chronic administration of fructose in the glycemic and lipidemic homeostasis and the intervention with the fish oil supplementation.
Student involved: Paola S Miranda
Related production: Sulis PM, Motta K, Barbosa AM, Besen MH, da Silva JS, Nunes EA, Rafacho A. Impact of Fish Oil Supplementation and Interruption of Fructose Ingestion on Glucose and Lipid Homeostasis of Rats Drinking Different Concentrations of Fructose. Biomed Res Int. 2017;2017:4378328. doi: 10.1155/2017/4378328. Epub 2017 Aug 8. PMID: 28929113; PMCID: PMC5591931.
17. Glycemic homeostasis in rats with loss of ovarian function and exposed to glucocorticoid excess.
Student involved: Francielle G Battiston
Related production: Battiston FG, Dos Santos C, Barbosa AM, Sehnem S, Leonel ECR, Taboga SR, Anselmo-Franci JA, Lima FB, Rafacho A. Glucose homeostasis in rats treated with 4-vinylcyclohexene diepoxide is not worsened by dexamethasone treatment. J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):170-181. doi: 10.1016/j.jsbmb.2016.06.001. Epub 2016 Jun 3. PMID: 27264932.
18. Endocrine pancreas adaptive compensation in pharmacological rat model of insulin resistance: sex- and age-related changes.
Students involved: Cristiane Santos, Francielle B D Ferreira & Luiz M Gonçalves-Neto
Related production: dos Santos C, Ferreira FB, Gonçalves-Neto LM, Taboga SR, Boschero AC, Rafacho A. Age- and gender-related changes in glucose homeostasis in glucocorticoid-treated rats. Can J Physiol Pharmacol. 2014 Oct;92(10):867-78. doi: 10.1139/cjpp-2014-0259. PMID: 25272090.
19. Effects of arjunolic acid administration on glucose homeostasis from glucocorticoid-treated rats.
Students involved: Francielle B D Ferreira & Luiz M Gonçalves-Neto
Related production: Gonçalves-Neto LM, Ferreira FB, Souza L, dos Santos C, Boschero AC, Facundo VA, Santos AR, Nunes EA, Rafacho A. Disruption of glucose tolerance caused by glucocorticoid excess in rats is partially prevented, but not attenuated, by arjunolic acid. Indian J Exp Biol. 2014 Oct;52(10):972-82. PMID: 25345246.
20. Evaluation of glucose homeostasis and metabolism in CLP-induced mice sepsis.
Students involved: Cristiane Santos, Francielle B D Ferreira & Luiz M Gonçalves-Neto
Related production: Ferreira FBD, Dos Santos C, Bruxel MA, Nunes EA, Spiller F, Rafacho A. Glucose homeostasis in two degrees of sepsis lethality induced by caecum ligation and puncture in mice. Int J Exp Pathol. 2017 Dec;98(6):329-340. doi: 10.1111/iep.12255. Epub 2017 Dec 11. PMID: 29226508; PMCID: PMC5826970.
21. Evaluation of key insulinic and inflammatory signal components in peripheral tissues from dexamethasone-treated rats.
Student involved: Katia Motta
Related production: Motta K, Barbosa AM, Bobinski F, Boschero AC, Rafacho A. JNK and IKKβ phosphorylation is reduced by glucocorticoids in adipose tissue from insulin-resistant rats. J Steroid Biochem Mol Biol. 2015 Jan;145:1-12. doi: 10.1016/j.jsbmb.2014.09.024. Epub 2014 Sep 28. PMID: 25268311.
22. Effects of acute intermittent hypoxia on rat glucose homeostasis.
Students involved: Francielle B D Ferreira & Luiz M Gonçalves-Neto
Related production: Rafacho A, Gonçalves-Neto LM, Ferreira FB, Protzek AO, Boschero AC, Nunes EA, Zoccal DB. Glucose homoeostasis in rats exposed to acute intermittent hypoxia. Acta Physiol (Oxf). 2013 Sep;209(1):77-89. doi: 10.1111/apha.12118. Epub 2013 Jun 8. PMID: 23692825.
23. Effects of beta-hidroxy-beta-methylbutyrate supplementation on glucose homoestasis from glucocorticoid-treated rats.
Students involved: Cristiane Santos, Francielle B D Ferreira & Luiz M Gonçalves-Neto
Related production: Nunes EA, Gonçalves-Neto LM, Ferreira FB, dos Santos C, Fernandes LC, Boschero AC, Calder PC, Rafacho A. Glucose intolerance induced by glucocorticoid excess is further impaired by co-administration with β-hydroxy-β-methylbutyrate in rats. Appl Physiol Nutr Metab. 2013 Nov;38(11):1137-46. doi: 10.1139/apnm-2012-0456. Epub 2013 Jun 17. PMID: 24053521.
